What it is: A nonirritating 0.3 percent retinol serum that rapidly smooths fine lines, wrinkles, and texture with breakthrough Malassezin technology.
Skin Type: Normal, Combination, and Sensitive
Skincare Concerns: Fine Lines and Wrinkles, Loss of Firmness and Elasticity, and Uneven Texture
Formulation: Serum
Highlighted Ingredients: - Malassezin: Patented ingredient 10X more powerful than vitamin C to target dark spots. - Encapsulated Retinol: Controlled-release retinol visibly fades lines while reducing sensitivity. - Lipid Concentrate: Concentrated lipid blend that mimics skin barrier to visibly plump skin. - Trehalose: Soothes skin and helps retain moisture for added comfort.
Ingredient Callouts: This product is vegan and cruelty-free.
What Else You Need to Know: This first-of-its-kind serum pairs Malassezin and retinol together, combining barrier support with gold-standard skin renewal. The synergistic formula delivers exponential results, smoothing texture and minimizing fine lines for visibly firmer, more radiant skin in as fast as four weeks.
Clinical Results: In a clinical study across 33 people using instrumentation, VISIA photography, expert grading, and consumer perception, after 4 weeks: - 94% had firmer skin and said fine lines and wrinkles looked minimized - 97% had more radiant skin - 100% said the product was gentle on their skin
Clean at Sephora Clean at Sephora is our commitment to offering effective products without certain ingredients, such as parabens, sulfates, phthalates, and mineral oils. Learn more here.
This is really a good product that I used it as a serum and actually it gives me the function as a serum. It’s easy to apply and absorbed by my skin. I like how it can make my skin smooth and hydrated. Will keep using it as my routine before cream for a while.
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Lydia127
Combination skin
Incentivized
5mos ago
Recommended
Must buy!!!
After using the Synergist Retinol Night Cream consistently, I'm genuinely impressed. As someone with sensitive-ish skin, I was terrified of the dreaded retinol purge and peeling. This formula, with its encapsulated retinol and that cocoon-like cream texture, was gentle enough for me to use nightly after a short adjustment period.
The results? My skin texture is noticeably smoother—like, silkier to the touch. I wake up with a real glow, and some fine lines around my eyes look softer. It hasn't been a miracle worker for deep wrinkles, but for overall brightness and refining, it's become a Holy Grail. It's pricey, but a little goes a long way. If you're retinol-curious but scared, this is a fantastic, gentle place to start.
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Fizmi
Dry skin
Incentivized
5mos ago
Recommended
Feel gentle on the skin!
This RETINOL SYNERGIST by Mother Science is a great option if you want to try retinol but with a gentler feel on the skin. I like that it feels lightweight and absorbs nicely without leaving the skin greasy or heavy. With consistent use, skin looks smoother and more balanced. It’s also a nice choice for anyone who wants a retinol product that works well in a skincare routine without feeling too harsh. I didn’t feel any discomfort, even when I started using it for the first time. It’s a great addition if you’re looking to target early signs of aging while keeping your skin looking healthy and glowing.
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sdiwan
Dry skin
Incentivized
5mos ago
Recommended
Must have retinol serum!
I really love this retinol synergist serum by Mother Science. It is lightweight and absorbs easily into the skin. I use it at night (started off every other night), followed by a hydrating moisturizer. I’ve noticed an improvement in the overall texture of my skin, as well as a more radiant appearance in the morning. Would ABSOLUTELY recommend!
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tbrooke2125
Combination skin
Incentivized
5mos ago
Recommended
Supports skin barrier
Lightweight, yet moisturizing for a retinol. I Immediately noticed this doesn’t dry out my skin. My skin barrier seems moisturized still which is hard to find from a retinol. Fine lines have improved as well as the overall texture and appearance of my skin.
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danibooo302
Combination skin
Incentivized
5mos ago
Recommended
Great gentle retinol option
While I've been using the serum (which has reached HG status) for the last 4 months, I've just added in the retinol a month ago using it 2x a week. So far my skin has reacted really well to the retinol (and traditionally my skin can be super sensitive to retinol and Vit C products) and i'm seeing a brightening effect already. I am hopeful that this in combination with the serum will give me soft glowy skin of my dreams.
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AtomsH20
Oily skin
Incentivized
5mos ago
Recommended
I’ve been using Retinol Synergist for weeks and I’m satisfied with this product. My fine lines got softer and less visible than before. I use it once in every 3 days before sleep and so far I haven’t had any irritations or reactions. The Retinol synergist serum is like a cream. It recommends to use a pea size. But it barely covered my whole face with a pea size amount when I put it first time. So I put moisturizing toner before applying the product to spread it easily. Overall I’m happy with this product. My skin is looking healthier, even tone and radiant. I recommend this product!
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KatieKanp
Combination skin
Incentivized
5mos ago
Recommended
I Am SOLD
I use this retinol with Mother Science Hero Serum and Mother Science Molecular Genesis moisturizer and swear by them! I've used their products religiously since their launch and so happy I can get them in-store now.
This retinol goes on easily and never burns. I only use it at night since you should never where it in the sun.
I always get compliments on my skin and questioned about the lack of crows feet that "should" be around my eyes. After only a month of using this product, my skin definitely felt softer and looked more hydrated without looking oily. After 2-3 months, my skin definitely looked brighter and nourished. The dark spots have lightened on my cheeks as well as vanishing on my upper lip.
Amazing products that I will never stop using!
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CoriLA
Oily skin
5mos ago
Recommended
This retinol is great. I introduced it by the sandwich method. Moisturizer retinol then more Moisturizer. It's gentle but effective in exfoliating the skin and reducing small wrinkles. The packaging is beautiful
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Kbra123
Combination skin
Incentivized
5mos ago
Recommended
I have been using the Mother Science Retinol Synergist for a few weeks and I am very pleased with how my skin looks. The texture is light, absorbs quickly, and feels comfortable even on my sensitive skin. My complexion appears smoother and brighter, and the dark spots and fine lines have become less visible. It leaves my skin feeling soft, hydrated, and healthy without any dryness or irritation
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shils
Dry skin
Incentivized
What it is: A nonirritating 0.3 percent retinol serum that rapidly smooths fine lines, wrinkles, and texture with breakthrough Malassezin technology.
Skin Type: Normal, Combination, and Sensitive
Skincare Concerns: Fine Lines and Wrinkles, Loss of Firmness and Elasticity, and Uneven Texture
Formulation: Serum
Highlighted Ingredients: - Malassezin: Patented ingredient 10X more powerful than vitamin C to target dark spots. - Encapsulated Retinol: Controlled-release retinol visibly fades lines while reducing sensitivity. - Lipid Concentrate: Concentrated lipid blend that mimics skin barrier to visibly plump skin. - Trehalose: Soothes skin and helps retain moisture for added comfort.
Ingredient Callouts: This product is vegan and cruelty-free.
What Else You Need to Know: This first-of-its-kind serum pairs Malassezin and retinol together, combining barrier support with gold-standard skin renewal. The synergistic formula delivers exponential results, smoothing texture and minimizing fine lines for visibly firmer, more radiant skin in as fast as four weeks.
Clinical Results: In a clinical study across 33 people using instrumentation, VISIA photography, expert grading, and consumer perception, after 4 weeks: - 94% had firmer skin and said fine lines and wrinkles looked minimized - 97% had more radiant skin - 100% said the product was gentle on their skin
Clean at Sephora Clean at Sephora is our commitment to offering effective products without certain ingredients, such as parabens, sulfates, phthalates, and mineral oils. Learn more here.
-Malassezin: Patented ingredient 10X more powerful than vitamin C to target dark spots. -Encapsulated Retinol: Controlled-release retinol visibly fades lines while reducing sensitivity. -Lipid Concentrate: Concentrated lipid blend that mimics skin barrier to visibly plump skin. -Trehalose: Soothes skin and helps retain moisture for added comfort.
The list of ingredients is subject to change. Please consult the packaging of the product purchased.
Suggested Usage: -In the evening, apply a pea-size amount of Retinol Synergist to clean, dry skin. -Start two to three times per week and gradually increase frequency as tolerated. -Always apply SPF during the day when using retinol products.
Summary
5
4
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5★
107 Reviews*
99%
Recommended
*Some reviewers received something in exchange for a review (free product, payment, sweeps entry).
